Press Release Details

View all news

Investigators Examine Brain Tests of Patients With COVID-19


In a Journal of Neuroimaging analysis of data obtained from 193 patients with COVID-19 who had brain and/or spine imaging and a lumbar puncture because of neurologic symptoms, investigators found that imaging results were related to the presence of SARS-CoV-2 in the cerebrospinal fluid. 

The results were called central nervous system hyperintense lesions and leptomeningeal enhancement. Ten percent of patients with hyperintense lesions in the brain/spine had a positive PCR test result for SARS-CoV-2 in the cerebrospinal fluid, compared with no patients without hyperintense lesions in the brain/spine. Twenty-five percent of patients with leptomeningeal enhancement had a positive PCR test result for SARS-CoV-2 in the cerebrospinal fluid, compared with 5% of patients without leptomeningeal enhancement. 

“Understanding the relationship between imaging and cerebrospinal fluid findings can improve understanding of neurological symptoms in patients with COVID-19. Although hyperintense lesions in the brain/spine and leptomeningeal enhancement are associated with the presence of SARS-CoV-2 in the cerebrospinal fluid, it is important to recognize that a positive SARS-CoV-2 PCR in the cerebrospinal fluid is uncommon. These imaging findings are predominantly the result of inflammation, hypoxia, or ischemia, rather than infection, of the central nervous system,” said lead author Ariane Lewis, MD, of NYU Langone Medical Center.

Additional Information

Link to Study:

About Journal

The Journal of Neuroimaging offers full coverage of all the relevant clinical neurological aspects of MRI, SPECT, Neurosonology, CT, PET, Transcranial Doppler, Carotid Ultrasound, and other neuroimaging modalities. This journal gives you the kind of practical information you can put to immediate use but cannot find elsewhere. Save valuable time by reading this one publication; you’ll learn the developments, research, equipment and reports that have the most meaning for you. Expert authors advise readers on the best techniques for maximum results and minimal risk. Carefully reproduced images illustrate the articles with clarity and fidelity. The articles and illustrations emphasize selecting the appropriate modality and using neuroimaging techniques to improve patient care. The Journal of Neuroimaging addresses the full spectrum of human nervous system disease including stroke, neoplasia, degenerative and demyelinating disease, epilepsy, infectious disease, toxic-metabolic disease, psychoses, dementias, heredo-familial disease and trauma. Each issue offers original clinical articles, case reports, articles on advances in experimental research, technology updates, and neuroimaging CPCs. 

About Wiley

Wiley drives the world forward with research and education. Through publishing, platforms and services, we help students, researchers, universities, and corporations to achieve their goals in an ever-changing world. For more than 200 years, we have delivered consistent performance to all of our stakeholders. The Company's website can be accessed at

Multimedia Files:

View all news