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In Vitro Fertilization Linked with Increased Risk of Congenital Heart Defects

A new analysis of published studies found a 45% increased risk of congenital heart defects in newborns when women become pregnant via in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) than through spontaneous conception.

Wednesday, November 22, 2017 2:46 am EST
"We believe that IVF/ICSI pregnancies present an increased risk of CHDs as a consequence of early placental dysfunction; however this hypothesis should be demonstrated in future studies. We recommend fetal echocardiography in all pregnancies from IVF/ICSI"

A new analysis of published studies found a 45% increased risk of congenital heart defects in newborns when women become pregnant via in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) than through spontaneous conception. The Ultrasound in Obstetrics and Gynecology analysis included 8 studies with 25,856 children obtained from IVF techniques and 287,995 children spontaneously conceived and a total of 2289 congenital heart defects.

Congenital heart defects were found in 1.30% and 0.68% in the IVF/ICSI and spontaneous conception groups, respectively.

"We believe that IVF/ICSI pregnancies present an increased risk of CHDs as a consequence of early placental dysfunction; however this hypothesis should be demonstrated in future studies. We recommend fetal echocardiography in all pregnancies from IVF/ICSI,” said lead author Dr. Paolo Cavoretto, of the IRCCS San Raffaele Hospital, in Milan, Italy.


Additional Information

Link to Study: http://onlinelibrary.wiley.com/doi/10.1002/uog.18932/full

About Journal

The Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG), Ultrasound in Obstetrics & Gynecology (UOG) is an international, peer-reviewed journal. Published monthly, the journal includes original papers, case reports, reviews, Editorial and Opinion articles, and a letters column. UOG is covered by all the primary indexes including Index Medicus and Current Contents, and is read by Obstetricians, Gynecologists, Radiologists, Pediatricians, Sonographers, Midwives and Radiographers.


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Contact:

Penny Smith
Tel: +44 (0)1243 770448
sciencenewsroom@wiley.com

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