Skip to main content

Building

A better future

through education, skill development and research

LEARN MORE

Study Points to the Futility of Urine Tests for Salbutamol Doping

Salbutamol, also known as albuterol, is a medication that opens up constricted medium and large airways in the lungs and is often used to treat asthma.

Thursday, May 3, 2018 7:24 am EDT
"If the doping community is determined to control for excessive salbutamol use, these procedures should be changed, ideally in collaboration with clinical pharmacologists."

Salbutamol, also known as albuterol, is a medication that opens up constricted medium and large airways in the lungs and is often used to treat asthma. Because high doses are suspected by some to also have an anabolic effect, its daily dosage is restricted by the World Anti-Doping Agency, which uses urine tests to determine violations. A new British Journal of Clinical Pharmacology study shows that large variability in urine concentrations, however, lead to infeasibility of determining an administered dose from a single untimed urine sample.

 

The authors noted that the current threshold inadvertently leads to incorrect assumptions of violation, whereas many violations will go unnoticed, especially when samples are taken long after drug administration. These issues, combined with the dubious assertion of its anabolic effect, indicate that the large effort involved in testing should be reconsidered.

 

“Using available pharmacological knowledge, we demonstrate that the current approach to detect excessive salbutamol use is fundamentally flawed and cannot differentiate between illegal and allowed use,” said co-author Jules Heuberger, of the Centre for Human Drug Research, in Leiden, The Netherlands. “If the doping community is determined to control for excessive salbutamol use, these procedures should be changed, ideally in collaboration with clinical pharmacologists.”


Media Contact:

Adam Cohen, Director

Centre for Human Drug Research

AC@chdr.nl

+31 (0) 715246400

Jules Heuberger

Senior Clinical Scientist

Centre for Human Drug Research

jheuberger@chdr.nl

+31(0) 715246400


Additional Information


Link to Study: https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bcp.13619

About Journal

Published on behalf of the British Pharmacological Society, the British Journal of Clinical Pharmacology contains papers and reports on all aspects of drug action in humans: review articles, mini review articles, original papers, commentaries, editorials and letters. The Journal enjoys a wide readership, bridging the gap between the medical profession, clinical research and the pharmaceutical industry. It also publishes research on new methods, new drugs and new approaches to treatment.

Multimedia Files:

Preview image

Contact:

Penny Smith
+44 (0) 1243 770448
sciencenewsroom@wiley.com

Business Wire NewsHQsm