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Weight Loss Surgery May Alter Gene Expression in Fat Tissue

New findings published in the Journal of Internal Medicine reveal altered gene expression in fat tissue may help explain why individuals who have regained weight after weight loss surgery still experience benefits such as metabolic improvements and a reduced risk of type 2 diabetes. 

Thursday, May 21, 2020 9:16 am EDT

Altered gene expression in fat tissue may help explain why individuals who have regained weight after weight loss surgery still experience benefits such as metabolic improvements and a reduced risk of type 2 diabetes. The findings come from a study published in the Journal of Internal Medicine.

The study included women who underwent weight loss surgery, and gene analyses were conducted before and two and five years after surgery. Analyses were also conducted in women who did not undergo surgery.

Most gene expression changes in fat tissue occurred during the first two years after surgery; however, a subset of genes encoding proteins involved in inflammation displayed a continued decrease in expression over five years (during weight regain).

Additional Information

Link to Study: https://onlinelibrary.wiley.com/doi/full/10.1111/joim.13066

About Journal 

The Journal of Internal Medicine (JIM) is published on behalf of the Association for Publication of the Journal of Internal Medicine and publishes original clinical work within the broad field of general and internal medicine and its sub-specialties.

About Wiley

Wiley drives the world forward with research and education. Through publishing, platforms and services, we help students, researchers, universities, and corporations to achieve their goals in an ever-changing world. For more than 200 years, we have delivered consistent performance to all of our stakeholders. The Company's website can be accessed at www.wiley.com.

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Contact:

Penny Smith +44 (0) 1243 770448 (UK)
newsroom@wiley.com

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