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Increasing Risk of Hospital-Treated Infections and Use of Antibiotics after Hip Fracture Surgery

In a Journal of Bone and Mineral Research study that examined trends in the incidence of infections following hip fracture surgery in Denmark, the risk of postoperative infections (at 15, 30, 90, and 365 days) increased between 2005 and 2016.

Wednesday, December 5, 2018 12:01 am EST
"Given the high mortality following infections in elderly individuals, future research and clinical work should focus on improving our understanding of the risk factors and patient profiles associated with postoperative infections. Knowledge of risk factors may enable cost-effective preventive measures and treatment protocols to reduce infections and mortality."

In a Journal of Bone and Mineral Research study that examined trends in the incidence of infections following hip fracture surgery in Denmark, the risk of postoperative infections (at 15, 30, 90, and 365 days) increased between 2005 and 2016.

The incidence of all hospital-treated infections within 30 days after hip fracture surgery increased by 32 percent, from 10.8 percent in 2005-2006 to 14.3 percent in 2015-2016. The risk of hospital-treated pneumonia within 30 days increased by 70 percent in 2015-2016 compared with 2005-2006. Community-based antibiotic prescriptions within 30 days after surgery increased by 54 percent, from 17.5 percent in 2005-2006 to 27.1 percent in 2015-2016.

The study—which included a total of 74,771 patients aged 65 years or older with first time hip fracture surgery—revealed that risk of infections was substantially higher in hip fracture patients than in the age- and gender-matched general population, and the risk of hospital-treated pneumonia and antibiotic prescriptions increased more over time among hip fracture patients.

"This nationwide study found increasing risk of hospital-treated infections and community-based antibiotic prescriptions after hip fracture surgery during the 12-year study period, which could not entirely be explained by increases seen in the general population,“ said lead author Kaja Kjørholt, of Aarhus University Hospital, in Denmark. ”Given the high mortality following infections in elderly individuals, future research and clinical work should focus on improving our understanding of the risk factors and patient profiles associated with postoperative infections. Knowledge of risk factors may enable cost-effective preventive measures and treatment protocols to reduce infections and mortality.“

Additional Information


Link to Study: https://onlinelibrary.wiley.com/doi/full/10.1002/jbmr.3620  


About Journal

The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases. 

About Wiley

Wiley is a global leader in research and education. Our online scientific, technical, medical, and scholarly journals, and our digital learning, assessment, certification and student-lifecycle services and solutions help universities, academic societies, businesses, governments and individuals to achieve their academic and professional goals. For more than 200 years, we have delivered consistent performance to our stakeholders. The Company's website can be accessed at www.wiley.com.


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