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Extended Tamoxifen Therapy May Increase Risk of Endometrial Cancer

There is clear evidence that extended adjuvant tamoxifen therapy for 10 years reduces local recurrence and improves breast cancer-free survival in women with oestrogen receptor–positive breast cancer. 

Thursday, July 5, 2018 12:01 am EDT
"There is a paucity of clear evidence on how we should best manage endometrial cancer risk in extended tamoxifen therapy. This is a research area that requires immediate focus with expansion of extended tamoxifen therapy regimes"

There is clear evidence that extended adjuvant tamoxifen therapy for 10 years reduces local recurrence and improves breast cancer-free survival in women with oestrogen receptor–positive breast cancer. An analysis of large randomized controlled trials, however, reveals that extended use is linked with a two-fold increased risk of developing endometrial (womb) cancer, when compared with standard 5 years of tamoxifen.

While more research is needed, the BJS (British Journal of Surgery) findings suggest that screening for endometrial cancer may be warranted in patients who receive extended tamoxifen therapy.

"There is a paucity of clear evidence on how we should best manage endometrial cancer risk in extended tamoxifen therapy. This is a research area that requires immediate focus with expansion of extended tamoxifen therapy regimes," said lead author Dr. Christina Fleming, of St. Vincent’s Hospital Group, in Dublin, Ireland. 

Additional Information

Link to Study: http://onlinelibrary.wiley.com/doi/10.1002/bjs.10899

About Journal

BJS (British Journal of Surgery) is the premier peer-reviewed surgical journal in Europe and one of the top surgical periodicals in the world, with an impact factor of 5.899. BJS is the official publication of the ASGBI, the Swiss Society of Surgery, the Swedish Surgical Society and the Sociedad Española de Investigaciones Quirúrgicas. Our global readership is also reflected in the prestigious international Editorial Board. BJS features the very best in clinical and laboratory-based research on all aspects of general surgery and related topics. BJS has a tradition of publishing high-quality papers in breast, upper GI, lower GI, vascular, endocrine and surgical sciences. Content includes Leading Articles, Reviews, Original Research Articles, Systematic Reviews, Meta-analyses and Randomized Clinical Trials.

About Wiley 

Wiley, a global research and learning company, helps people and organizations develop the skills and knowledge they need to succeed. Our online scientific, technical, medical, and scholarly journals, combined with our digital learning, assessment and certification solutions help universities, learned societies, businesses, governments and individuals increase the academic and professional impact of their work. For more than 210 years, we have delivered consistent performance to our stakeholders. The company's website can be accessed at www.wiley.com.

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