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Can Adverse Childhood Experiences Worsen Lupus Symptoms?

Adverse childhood experiences (ACEs) encompass traumas such as abuse, neglect, and household challenges. In an Arthritis Care & Research study of adults with lupus, higher ACE levels, as well as the presence of ACEs from each of these three domains, were associated with worse patient-reported accounts of disease activity, organ damage, depression, physical function, and overall health status.


Thursday, May 9, 2019 12:01 am EDT
"More than half of participants with lupus reported ACE exposure, many of whom experienced substantial trauma in childhood. There is a clear difference in patient-reported outcomes with cumulative ACE exposure in these individuals"

Adverse childhood experiences (ACEs) encompass traumas such as abuse, neglect, and household challenges. In an Arthritis Care & Research study of adults with lupus, higher ACE levels, as well as the presence of ACEs from each of these three domains, were associated with worse patient-reported accounts of disease activity, organ damage, depression, physical function, and overall health status.

In the study of 269 patients, more than 60 percent identified at least one ACE, and more than 15 percent indicated at least four ACEs.

“More than half of participants with lupus reported ACE exposure, many of whom experienced substantial trauma in childhood. There is a clear difference in patient-reported outcomes with cumulative ACE exposure in these individuals,” said lead author Dr. Kimberly DeQuattro, of the University of California, San Francisco. “This work in lupus supports more broadly the body of studies on adversity and trauma in childhood that have found a link between ACEs and health. It is a call to action to focus efforts on ACE prevention in childhood as well as clinical and mental health interventions that foster resilience in adulthood.” 

Additional Information

Link to Study: https://onlinelibrary.wiley.com/doi/full/10.1002/acr.23878 

About Journal 

Arthritis Care & Research, an official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the College), is a peer-reviewed publication that publishes original research, review articles, and editorials that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with rheumatic diseases, major topics are evidence-based practice studies, clinical problems, practice guidelines, educational, social, and public health issues, health economics, health care policy, and future trends in rheumatology practice.

About Wiley

Wiley is a global leader in research and education. Our online scientific, technical, medical, and scholarly journals, and our digital learning, assessment, certification and student-lifecycle services and solutions help universities, academic societies, businesses, governments and individuals to achieve their academic and professional goals. For more than 200 years, we have delivered consistent performance to our stakeholders. The Company's website can be accessed at www.wiley.com.

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