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  • November 27, 2017
    Nerve growth factor signals through receptors of the tropomyosin-related kinase (Trk) family, and research in animals has shown that inhibitors of Trks A, B, and C can reduce pain. Now a new study in the British Journal of Clinical Pharmacology provides the first demonstration of pain relief in humans using a Trk inhibitor. The inhibitor was compared with pregabalin, ibuprofen, and placebo, in randomized, double blind, cross-over study with 20 participants. “One striking aspect of...
  • November 27, 2017
    New research indicates that the prevalence of arthritis in the United States has been substantially underestimated, especially among adults <65 years old. The Arthritis & Rheumatology findings indicate that research is needed to better monitor arthritis prevalence in the US population and to develop better prevention strategies.Current national estimates of arthritis rely on a single survey question, asking participants whether they remember being ever told by a health professional that...
  • November 22, 2017
    A new Papers in Regional Science article that highlights the possible implications of Brexit for the UK and its regions notes that the results for the UK economy may not be as damaging as some forecasters say. The authors point out that there have been numerous differing forecasts at the national level concerning the impact of Brexit. They concentrate on the forecasts by Her Majesty’s Treasury (HMT), the Cambridge Centre for Business Research, and the Economists for Brexit....
  • November 22, 2017
    In a recent study of adolescents, the benefits of cognitive-behavioral sleep interventions were greatest among individuals with higher levels of anxiety and depressive symptoms. The results, which are published in the Journal of Child Psychology and Psychiatry were consistent across genders. “We know there is a strong link between emotional problems, like anxiety and depression, and sleep problems. In the past some researchers and clinicians have thought that these emotional problems might...
  • November 22, 2017
    A recent Indoor Air study found that opening windows or doors before going to bed can reduce carbon dioxide levels in bedrooms and improve sleep quality. Participants subjective assessment of their sleep depth, which was obtained through questionnaires, correlated with carbon dioxide levels. Objectively measured sleep efficiency and number of awakenings, which were assessed through senses worn during sleep, also correlated with carbon dioxide levels. Lower carbon dioxide levels implied better...
  • November 22, 2017
    Researchers have discovered a new marker of arthritis in mice that can be used non-invasively to both identify joints with established arthritis and to predict subsequent joint swelling. The finding is published in Arthritis & Rheumatology. The investigators note that imaging tests with the marker—called Ratiometric thrombin-Activatable Cell Penetrating Peptide—might help clinicians monitor the development and progression of arthritis and other inflammatory diseases. “This new imaging tool...
  • November 22, 2017
    In an Arthritis Care & Research study of individuals who underwent total knee replacement, those who did not attend college had worse pain and function after two years if they lived in poor communities, but educational level was not linked with pain or function in wealthy communities. How education might protect those in impoverished communities warrants further study. “This study illustrates the complex ways that social factors interact, and the importance of analyzing contextual factors...
  • November 22, 2017
    A new analysis of published studies found a 45% increased risk of congenital heart defects in newborns when women become pregnant via in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) than through spontaneous conception. The Ultrasound in Obstetrics and Gynecology analysis included 8 studies with 25,856 children obtained from IVF techniques and 287,995 children spontaneously conceived and a total of 2289 congenital heart defects. Congenital heart defects...
  • November 22, 2017
    A new study provides insights into the interaction between alcohol consumption and metabolic factors in predicting severe liver disease in the general population. The findings, which are published in Hepatology, indicate that multiple components of the metabolic syndrome affect the risk of severe liver disease in conjunction with alcohol consumption at levels that are typically thought to not cause liver damage.Worldwide there is an increasing burden of liver disease and liver cancer. The...
  • November 22, 2017
    Biosimilars have been available in the European Union since 2006. A new British Journal of Clinical Pharmacology analysis of publicly available regulatory documents found no substantial differences in the reporting of safety information for biosimilars and related originators.The analysis included 19 biosimilars and 6 originators. Overall, 55 general safety concerns (12 low, 21 medium, and 22 highly clinically relevant) were identified. For all substances, except for infliximab, no or only one...