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  • May 04, 2017
    Wiley, Publishing Partners Engage to Support Science.Hoboken, NJ—May 4, 2017—Evidence-based science is at the heart of discoveries that transform our world. From the development of life-saving antibiotics to the resolution of climate change issues; from the reversal of social injustices to the furthering of space exploration, collaborative research has set the foundation for a brighter future.On April 22, 2017, the March for Science took place in Washington, DC and more than 600 satellite...
  • May 04, 2017
    A new study questions the use of common references for assessing ‘small for gestational age’ (SGA) in very preterm infants across Europe. SGA describes a baby who is smaller than the usual amount for the number of weeks of pregnancy.In the study, investigators generated a common European reference for determining SGA as well as country-specific references for 11 participating countries using the countries' average birthweights at term.When using the common European reference, SGA in very...
  • May 04, 2017
    Why is sex so popular among plants and animals, and why isn’t asexual reproduction, or cloning, a more common reproductive strategy?Researchers recently tested a theory developed in the 1970s by John Maynard Smith suggesting that sex is a more costly reproductive strategy than asexual reproduction. Mathematically, he showed that asexual females make more grandchildren than sexual females. For sexual females, approximately half their offspring must be sons, and those sons can’t physically bear...
  • May 04, 2017
    Most tumors contain regions of low oxygen concentration where cancer therapies based on the action of reactive oxygen species are ineffective. Now, American scientists have developed a hybrid nanomaterial that releases a free-radical-generating prodrug inside tumor cells upon thermal activation. As they report in the journal Angewandte Chemie, the free radicals destroy the cell components even in oxygen-depleted conditions, causing apoptosis. Delivery, release, and action of the hybrid...
  • May 04, 2017
    New research provides insights into why infection with Zika virus after birth generally causes only mild symptoms, whereas devastating fetal malformations can develop when infection occurs during pregnancy.Healthy people are protected by antiviral factors of our innate immune system. Investigators have now shown that reducing levels of one antiviral factor called interferon-induced transmembrane protein 3 (IFITM3) makes cultured cells highly sensitive to Zika virus infection.The team found...
  • May 04, 2017
    A new study using data from the Osteoarthritis Initiative, a multi-center observational study of nearly 3500 participants, indicates that people who hear grating, cracking, or popping sounds in or around their knee joint may be at increased risk of developing knee osteoarthritis.This was a study of people who were at high risk for developing knee osteoarthritis. Among those who developed it within a year, more than 75% had signs of osteoarthritis on radiographic images but...
  • May 04, 2017
    A new analysis finds that, despite advances in care, men and women with a diagnosis of heart failure continue to have worse survival rates than patients with certain common cancers.The study included 56,658 adults in Scotland who were receiving care in a primary care setting, with a total of 147,938 person-years of follow-up. In men, heart failure was linked with worse survival than prostate cancer and bladder cancer, but better survival than lung cancer and colorectal cancer. In women, heart...
  • May 04, 2017
    A new study finds that delivery of oxygen via high-flow nasal tubes may help patients who experience exacerbations of chronic obstructive pulmonary disease (COPD).In the 24-patient cross-over trial, short-term use of nasal high-flow cannulae at 35 L/min resulted in lower levels of retained carbon dioxide compared with standard nasal prongs, but whether this is clinically significant is uncertain.“These findings suggest that this novel way of delivering oxygen therapy to patients with an...
  • May 04, 2017
    An analysis of published studies found that in individuals with epilepsy, there is a 20.2% prevalence of anxiety disorders and a 22.9% prevalence of depression. Investigators also found no differences in the prevalence of either depression or anxiety based on the severity of illness.Improving our understanding, detection, and management of both anxiety and depressive disorders in people with epilepsy is crucial to providing optimal care for affected patients.“It is often thought that...
  • May 04, 2017
    A new study estimates that the lifetime risk of symptomatic hand osteoarthritis is 40%, and nearly one in two women and one in four men will develop the condition, which affects hand strength and function and causes disability in activities of daily living.Race-specific estimates are 41% among whites and 29% among blacks. Also, the lifetime risk among individuals with obesity is 47%, which is 11 percentage points higher than those without obesity.These findings indicate that hand...