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  • December 06, 2017
    Nature has evolved sugars, amino acids, and special antifreeze proteins as cryoprotectants. People use organic solvents and synthetic polymers as additives to prevent cell cultures from freezing damage. Now, English scientists have combined both methods: In work published in the journal Angewandte Chemie, they introduced polyproline, a polypeptide made of the natural amino acid proline, as an effective cryoprotectant for monolayers of cells.The living cell is very vulnerable to freezing and...
  • December 06, 2017
    HOBOKEN, N.J.--(BUSINESS WIRE)--John Wiley and Sons Inc. (NYSE:JWA)(NYSE:JWB), a global research and learning company, today announced results for the second quarter ending October 31, 2017. HIGHLIGHTS Revenue increased 6% to $452 million; +3% at constant currency Adjusted EPS increased 32% to $1.03; +22% at constant currency. EPS on a GAAP basis at $1.04, up from ($0.20) Free Cash Flow less Product Development...
  • December 06, 2017
    Biosimilars are biologic agents that highly similar to original biomedical medications (oringinators), but are much cheaper. A new study in Alimentary Pharmacology & Therapeutics found no differences in drug levels and disease activity between infliximab originator and an infliximab biosimilar in patients with inflammatory bowel disease, indicating that this biosimilar is indeed safe and effective.  After switching to an infliximab biosimilar, 26% of patients discontinued...
  • December 06, 2017
    In a Pediatric Pulmonology study of children aged 15 months, increasing hair nicotine levels were related to prior parent-reported smoking exposure and were associated with potential increased risks of wheeze and asthma.In the study of 376 infants, researchers obtained detailed information from parents about smoking exposure during pregnancy and in the home at 3 and 15 months of age. Data for demographics, wheezing, and asthma were obtained from yearly questionnaires up to age 6 years. ...
  • December 06, 2017
    In an Arthritis Care & Research analysis of 6661 participants in the Australian Longitudinal Study on Women's Health, maintaining at least low levels of physical activity throughout middle age was associated with lower prevalence and incidence of joint symptoms later in life. The potential protective effect of physical activity on joint symptoms was stronger in obese women than in under or normal weight women, and it was not related to menopausal status or use of hormone therapy.Additional...
  • December 06, 2017
    Many deceased donor kidneys are declined for transplantation because of concerns over their quality, but a new BJS (British Journal of Surgery) study found that a technique called normothermic machine perfusion can assess the quality of a kidney and determine its suitability for transplantation. “Of five kidneys that would normally be discarded but were found suitable by the technique, four functioned immediately after transplantation,” said lead author Dr. Sarah Hosgood, of the University of...
  • December 06, 2017
    In a recent study, investigators found that certain changes in the brain that occurred after limb amputation in a child were reversible after restoring sensory input through bilateral hand transplantation. The findings are published in the Annals of Clinical and Translational Neurology.“We are still learning exactly how these large-scale changes in the brain’s representation of the body occur; however, our data show that such changes can be reversed once sensory input is restored (such as via...
  • December 06, 2017
    Physical activity can benefit patients with heart failure with preserved ejection fraction, a common condition with no pharmacological treatment, but no clear recommendations exist on the optimal amount or intensity of physical activity for these patients.A new ESC Heart Failure study found that a higher amount of physical activity is related to higher sub-maximal exercise capacity and physical dimensions of quality of life; however, only high-intensity exercise...
  • December 06, 2017
    The error-related negativity (ERN) is a brain signal response to errors that is thought to reflect threat sensitivity and has been implicated in anxiety disorders in individuals without autism spectrum disorder (ASD). A new Autism Research study has revealed that the ERN is related to social anxiety symptoms—specifically performance fears—in youth with ASD. The findings suggest that heightened threat sensitivity may be characteristic of people with ASD who exhibit social fearfulness. Those...
  • December 06, 2017
    In a Journal of the American Geriatrics Society study, a blood-based precision medicine test incorporating age, sex, and gene expression score (ASGES) was helpful in evaluating older outpatients with symptoms suggestive of obstructive coronary artery disease (CAD). In the study of 176 stable, non-acute outpatients presenting with symptoms suggestive of obstructive CAD who were aged 65 and older, participants with low scores with low likelihood of obstructive CAD were referred for further...