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New Test To Rapidly Diagnose Sepsis

Researchers have developed a test that can rapidly and reliably diagnose sepsis, a potentially life-threatening complication of bacterial infections.

Wednesday, May 17, 2017 12:01 am EDT
"Interestingly, pathogens in some blood culture–negative cases of sepsis patients were still detected in this study. We speculate that the residual DNA fragments of the bacteria might be detected by this system even if they were destroyed by antibacterial drugs or the immune system"

Researchers have developed a test that can rapidly and reliably diagnose sepsis, a potentially life-threatening complication of bacterial infections.

Rapid diagnosis of sepsis in hospitalized patients is crucial because in severe cases, there is an average 7.6% decrease in survival rate per hour from the onset of low blood pressure without effective antimicrobial treatment. Early identification of a pathogen increases the chance of targeting the correct agent and may avoid misuse of antibiotics.

In a Journal of Clinical Laboratory Analysis study, investigators describe what is called a TaqMan-Based Multiplex real-time PCR detection system, which allowed for rapid detection of 10 of the most frequent bacterial pathogens from blood samples.

 “Interestingly, pathogens in some blood culture–negative cases of sepsis patients were still detected in this study. We speculate that the residual DNA fragments of the bacteria might be detected by this system even if they were destroyed by antibacterial drugs or the immune system,” said Dr. Bing Zhang, senior author of the study.

Additional Information

Link to Study: http://doi.wiley.com/10.1002/jcla.22256

About Journal

Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.

 

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