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New Strategy May Help Combat Alzheimer’s Disease

Researchers have uncovered a mechanism that helps block the accumulation of proteins involved in Alzheimer’s disease. Tapping into this natural process may therefore help prevent or treat the condition.

Tuesday, March 14, 2017 10:37 am EDT
"We have found that a type of nucleic acid found in brains of healthy individuals reduces the level of BACE-1 by promoting its degradation"

Researchers have uncovered a mechanism that helps block the accumulation of proteins involved in Alzheimer’s disease. Tapping into this natural process may therefore help prevent or treat the condition.

Alzheimer’s disease is characterized by the build-up of amyloid-beta fragments in the brain. There is hope that reducing levels of the enzyme BACE-1, which cleaves larger proteins into these fragments, might help treat the disease.

“We have found that a type of nucleic acid found in brains of healthy individuals reduces the level of BACE-1 by promoting its degradation,” said Dr. Wei Hong, senior author of The FEBS Journal article.


Additional Information

Link to study: http://onlinelibrary.wiley.com/doi/10.1111/febs.14045/full

About Journal

The FEBS Journal is an international Journal devoted to the rapid publication of full-length papers covering a wide range of topics in any area of the molecular life sciences. The criteria for acceptance are originality and high quality research, which will provide novel perspectives in a specific area of research, and will be of interest to our broad readership.

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