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Researchers Compare Drugs for Treating Severe Hypertension in Pregnancy

A recent meta-analysis of published studies has compared the efficacy and safety of antihypertensive drugs during pregnancy.

Thursday, July 5, 2018 12:01 am EDT

A recent meta-analysis of published studies has compared the efficacy and safety of antihypertensive drugs during pregnancy.

In the British Journal of Clinical Pharmacology, investigators reported similar efficacy between nifedipine, hydralazine, and labetalol, and negligible differences were observed in their safety profile. The available evidence was inadequate for other drugs. Moderate quality of evidence was observed for direct comparison estimates between labetalol and hydralazine, but was either low or very low for other comparisons.


Labetalol, hydralazine, and nifedipine are likely comparable for treating acute-onset, severe hypertension in pregnancy, noted the authors, Dr. Kannan Sridharan and Prof. Reginald Sequeira, of Arabian Gulf University, in Bahrain.

Additional Information

Link to study:

 http://onlinelibrary.wiley.com/doi/10.1111/bcp.13649

About Jounal

Published on behalf of the British Pharmacological Society, the British Journal of Clinical Pharmacology contains papers and reports on all aspects of drug action in humans: review articles, mini review articles, original papers, commentaries, editorials and letters. The Journal enjoys a wide readership, bridging the gap between the medical profession, clinical research and the pharmaceutical industry. It also publishes research on new methods, new drugs and new approaches to treatment.

About Wiley 

Wiley, a global research and learning company, helps people and organizations develop the skills and knowledge they need to succeed. Our online scientific, technical, medical, and scholarly journals, combined with our digital learning, assessment and certification solutions help universities, learned societies, businesses, governments and individuals increase the academic and professional impact of their work. For more than 210 years, we have delivered consistent performance to our stakeholders. The company's website can be accessed at www.wiley.com.


Peer Reviewed, Meta-analysis, Human


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