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Study Examines Safety and Effectiveness of Infliximab Biosimilar in Patients with Inflammatory Bowel Disease

Biosimilars are biologic agents that highly similar to original biomedical medications (oringinators), but are much cheaper.

Wednesday, December 6, 2017 4:22 am EST
"Switching to biosimilars and performing therapeutic drug monitoring as part of routine care can optimize infliximab therapy of inflammatory bowel disease efficiently and make it more cost-effective"

Biosimilars are biologic agents that highly similar to original biomedical medications (oringinators), but are much cheaper. A new study in Alimentary Pharmacology & Therapeutics found no differences in drug levels and disease activity between infliximab originator and an infliximab biosimilar in patients with inflammatory bowel disease, indicating that this biosimilar is indeed safe and effective.

 

After switching to an infliximab biosimilar, 26% of patients discontinued therapy within 12 months. This high rate of discontinuation was likely due to elective withdrawal or subjective disease worsening.

 

“Switching to biosimilars and performing therapeutic drug monitoring as part of routine care can optimize infliximab therapy of inflammatory bowel disease efficiently and make it more cost-effective,” said senior author Dr. Luc Derijks, of the Máxima Medical Center, in The Netherlands.

Additional Information

Link to Study: http://onlinelibrary.wiley.com/doi/10.1111/apt.14453/full

About Journal

Alimentary Pharmacology & Therapeutics is an international journal of gastroenterology and hepatology.

The journal accepts original papers and systematic reviews concerned with clinical gastroenterology, hepatology and endoscopy.

AP&T is particularly interested in therapies and diagnostics, including all aspects of translation from bench to bedside: identification of novel therapeutic targets, epidemiology, clinical trials, drug safety and meta-analyses.

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